Journal issues > Issue 4, June 2022 > Acalabrutinib, a next-generation Bruton’s tyrosine kinase inhibitor

Acalabrutinib, a next-generation Bruton’s tyrosine kinase inhibitor

By: T. Van Nieuwenhuyse PharmD, A. Janssens MD, PhD

SUMMARY

Bruton’s tyrosine kinase (BTK) inhibitors have demonstrated impressive clinical activity and tolerability in several B-cell malignancies, both as single agent or in combination with anti-CD20 monoclonal antibodies. Acalabrutinib, a next-generation BTK inhibitor, has been reimbursed recently by the Belgian national public health insurance for the treatment of chronic lymphocytic leukaemia (CLL). This review describes mechanism of action, dosage and administration, efficacy, and tolerability.

(BELG J HEMATOL 2022;13(4):156–64)

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