Journal issues > Issue 8, December 2022 > Haematological echoes from ESMO 2022

Haematological echoes from ESMO 2022

SUMMARY

While the annual meeting of the European Society for Medical Oncology (ESMO) of course mainly focusses on advances in solid tumours, this year’s edition also featured a session zooming on haematological malignancies. In this session, encouraging results were presented for the combination of lemzoparlimab, a CD47 antibody, with azacytidine, in the treatment of patients with myelodysplastic syndromes. In addition, also the new anti-CD20-MMAE antibody-drug conjugate TRS005 displayed promising activity in patients with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma. Finally, two interesting studies were presented using novel CAR-T constructs, one CAR-T expressing a PD1 knock-down gene for the treatment of CD19+ B cell malignancies, and a second CAR-T construct targeting BCMA, for the treatment of R/R myeloma.

(BELG J HEMATOL 2022;13(8):333–6)

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