Journal issues > Issue 5, September 2024 > Highlights in chronic lymphocytic leukaemia

Highlights in chronic lymphocytic leukaemia

SUMMARY

At EHA 2024 new information on TP53 mutations in chronic lymphocytic leukemia (CLL) were presented together with preliminary or more mature data on doublets and triplets of novel agents. In the session on novel therapies in relapsed/refractory (R/R) CLL we were informed on the preliminary efficacy and safety of two BTK degraders (BGB-16673,NX-5948) and on the results of the bcl-2 inhibitor sonrotoclax in combination with zanubrutinib. Preliminary results on characteristics associated with response to lisocabtagene maraleucel (Liso-cel) in R/R CLL were also communicated.

(BELG J HEMATOL 2024;15(5):184–89)

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