BJH - volume 5, issue Abstract Book BHS, january 2014
J. Van Der Straeten MSc, B. De Moerloose MD, PhD, M-F. Dresse MD, PhD, S. Dupont MD, A. Ferster MD, PhD, P. Philippet MD, A. Uyttebroeck MD, PhD, J. Van der Werf ten Bosch , C. Demanet MD, PhD, Y Benoit MD, PhD, M. Bakkus PhD
BJH - volume 4, issue 3, september 2013
A. Ferster MD, PhD, B. Gulbis MD, PhD
During the twelfth meeting dedicated to sickle cell disease and hereditary red cell disorders held in Brussels on 21 February 2013, several topics related to major aspects for the management of sickle cell disease were presented. Six of them are summarised.
(BELG J HEMATOL 2013;4(3): 115–116)
Read moreBJH - 2013, issue BHS Abstractbook, january 2013
H.H. Helsmoortel , T. Lammens PhD, N. Van Roy PhD, A. Uyttebroeck MD, PhD, A. Ferster MD, PhD, Y Benoit MD, PhD, F. Speleman PhD, B. De Moerloose MD, PhD
BJH - 2013, issue BHS Abstractbook, january 2013
D. Noubouossie MD, F. Ziereisen , P.-Q. Le , D. Willems , B. Mahadeb , L. Rozen PharmD, M. Ngalula Mujinga , A. Demulder MD, PhD, A. Ferster MD, PhD
BJH - 2013, issue BHS Abstractbook, january 2013
P.-Q. Le , B. Gulbis MD, PhD, L. Dedeken , C. Heijmans , A. Vanderfaeillie MD, C. Vermylen , S. Huybrechts MD, C. Devalck , F. Cotton , B.C. Nguyen , F. Vertongen , M. Ngalula , A. Ferster MD, PhD
BJH - volume 3, issue 2, june 2012
S. Huybrechts MD, Y. Beguin MD, PhD, V. Bordon MD, PhD, MF. Dresse , S. Dupont MD, A. Ferster MD, PhD, G. Laureys MD, PhD, I. Meyts , M. Renard , C. Vermylen
Busulfan is commonly used in preparative conditioning regimens prior to haematopoietic stem cell transplantation in children and young adults for malignant and non-malignant disorders. For many years busulfan was only available in oral form, resulting in large inter- and intra-patients variability in plasma exposure, associated with higher graft failure rate as well as higher toxicity such as veno-occlusive disease. With the development of an intravenous formulation of busulfan, a more accurate control of both the inter- and intra-patient variability has been provided. The goal of this study was to evaluate the use and efficacy of intravenous busulfan in comparison with the oral formulation in children undergoing an autologous transplantation after conditioning with busulfan. Despite the small number of patients, this study confirmed the apparent benefit of intravenous busulfan in children undergoing an autologous HSCT. The use of a five-level dose schedule defined by body weight resulted in an efficient engrafitment with marked reduction in the incidence of veno-occlusive disease compared with oral busulfan. In terms of disease-free outcome, survival and event-free survival, similar results have been obtained in both groups. The choice of this formulation of busulfan should therefore be considered.
(BELG J HEMATOL 2012;3:34–40)
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