Articles

A-128 PREVALENCE OF HETEROZYGOUS TYPE 2N VON WILLEBRAND DISEASE MUTATIONS IN BELGIUM

BJH - volume 8, issue Abstract Book BSTH, february 2017

J. Jongenotter , I. Vangenechten , K. Jochmans MD, PhD, C. Orlando , A. Gothot MD, PhD, K. Vandenbosch , A. Gadisseur MD, PhD

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P1.02 Hypercalcemia and osteolytic bone lesions in adult B-cell lymphoblastic leukemia: a rare but potentially life-threatening presentation

BJH - volume 7, issue Abstract Book BHS, january 2016

N.C. Granacher MD, L. Rutsaert MD, Z. Berneman MD, PhD, W. Schroyens MD, PhD, L. Lammertijn , A. Van De Velde MD, PhD, A. Verlinden MD, A. Gadisseur MD, PhD

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Systemic capillary leak syndrome as a prodrome of extranodal natural killer (NK)/T-cell lymphoma

BJH - volume 5, issue 4, december 2014

B. Hodossy MD, I. Vrelust MD, S. Anguille MD, PhD, V. Van Marck MD, PhD, M. Maes PhD, PharmD, K. Vermeulen PhD, A. Van De Velde MD, PhD, A. Gadisseur MD, PhD, W. Schroyens MD, PhD, Z. Berneman MD, PhD

Summary

We present the case of a 58-year-old male patient with a long-standing, intermittent oedema of the lower extremities and significant spontaneous variations in haematocrit values. Repeated examinations failed to reveal a clear etiology until the patient suffered from a severely painful exacerbation of leg oedema and hypotension. Laboratory analysis showed hypoalbuminemia. The combination of oedema, hypotension, hypoalbuminemia and hemoconcentration was indicative of a systemic capillary leak syndrome. This condition is known to be associated with monoclonal gammopathy, as was the case in our patient. New investigations showed suspicious lesions in the nasopharynx, scrotum and breast. Biopsies of this breast mass as well as bone marrow biopsy showed the presence of an extranodal natural killer/T-cell lymphoma, nasal type. Polychemotherapy was administered according to the SMILE schedule leading to a remission after two cycles. The patient then underwent autologous hematopoietic stem cell transplantation. The patient is currently without signs of systemic capillary leak syndrome. This report illustrates that systemic capillary leak syndrome may occur as a prodrome of haematological malignancies, such as natural killer/T-cell lymphoma and documents that it is responsive to chemotherapy.

(BELG J HEMATOL 2014;5(4):148–53)

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A-108 Belgian multicenter study into von Willebrand Disease (B-Will Study): First results

BJH - 2014, issue Abstract Book BSTH, november 2014

I. Vangenechten , K. Jochmans MD, PhD, P. Péters , K. Devreese , C. Hermans MD, PhD, S. Motte , A. Gadisseur MD, PhD

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P4.09 A novel HLA-C null variant allele (C*05:XXN) generated by single nucleotide deletion and premature stop codon in exon 3

BJH - volume 5, issue Abstract Book BHS, january 2014

B. Cauwelier MD, PhD, W. Rosseel , F. Nollet PhD, MSc, W. Schroyens MD, PhD, A. Gadisseur MD, PhD, Z. Berneman MD, PhD

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P.17 Complete responses of the TEMPI syndrome to bortezomib

BJH - 2013, issue BHS Abstractbook, january 2013

W. Schroyens MD, PhD, Z. Berneman MD, PhD, A. Gadisseur MD, PhD, A. Van De Velde MD, PhD, I. Vrelust MD

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P.24 Neurolymphomatosis: 2 cases diagnosed with FDG PET

BJH - 2013, issue BHS Abstractbook, january 2013

I. Bruynseels , S. Ceyssens , A. Van De Velde MD, PhD, W. Schroyens MD, PhD, A. Gadisseur MD, PhD, Z. Berneman MD, PhD, I. Vrelust MD

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