Articles

P.09 Exome sequencing identifies mutation of CNOT3 in T-cell acute lymphoblastic leukaemia

BJH - 2013, issue BHS Abstractbook, january 2013

C. Vicente , K. De Keersmaecker PhD, Z.K. Atak , J. Yan , N. Li , V. Gianfelici , E. Geerdens , E. Clappier , G. Hulselmans , R. Vande poel , B. Cauwelier MD, PhD, J. Cloos , J. Soulier , A. Uyttebroeck MD, PhD, B. Hassan , P. Vandenberghe MD, PhD, S. Aerts , J. Cools

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P.10 Role of HH pathway in T cell acute lymphoblastic leukaemia (T-ALL)

BJH - 2013, issue BHS Abstractbook, january 2013

A. Dagklis , D. Pauwels , I. Lahortiga , Z.K. Atak , K. De Keersmaecker PhD, K. Jacobs PhD, N. Mentens , A. Uyttebroeck MD, PhD, J. Maertens MD, PhD, G. Verhoef MD, PhD, S. Aerts , P. Vandenberghe MD, PhD, J. Cools

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P.31 Study of the miRNome of childhood myelodysplastic syndrome

BJH - 2013, issue BHS Abstractbook, january 2013

H.H. Helsmoortel , T. Lammens PhD, N. Van Roy PhD, A. Uyttebroeck MD, PhD, A. Ferster MD, PhD, Y Benoit MD, PhD, F. Speleman PhD, B. De Moerloose MD, PhD

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P.71 Swachman-Diamond Syndrome: Frequent misdiagnosis as Jeune Syndrome and other peculiarities

BJH - 2013, issue BHS Abstractbook, january 2013

I. Meyts , H. Schaballie , F. Haerynck MD, PhD, L. Sevenants , C. Vermylen , V. Bordon MD, PhD, X. Bossuyt , A. Corveleyn , A. Uyttebroeck MD, PhD, M. Renard

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Pseudohyperkalaemia in T-ALL: how to avoid life-threatening hypokalaemia

BJH - volume 3, issue 1, march 2012

N. Reynaert MD, V. Labarque MD, PhD, A. Uyttebroeck MD, PhD, E. Levtchenko MD, PhD, M. Renard

Summary

Tumour lysis syndrome is a well-known life-threatening complication in children with acute leukaemia and hyperleukocytosis. It is characterised by hyperkalaemia but it should be distinguished from pseudohyperkalaemia. Various underlying factors for this phenomenon of pseudohyperkalaemia have been suggested. Here, we describe two children with T-cell acute lymphoblastic leukaemia who presented with hyperleukocytosis and hyperkalaemia, in whom the diagnosis of pseudohyperkalaemia was made. We demonstrate that in extreme leukocytosis the use of a vacuum system, pneumatic transport, and sample centrifugation contribute all together to pseudohyperkalaemia. As the leukocyte count decreases, plasma potassium levels are more reliable. Based on our results we suggest to measure potassium in a whole blood sample immediately brought to the laboratory for minimising false results due to ex vivo cell lysis.

(BELG J HEMATOL 2012;3:12–6)

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