C. Hermans MD, PhD

A-131 SUCCESSFUL AND COST-EFFECTIVE USE OF FC-FUSED FIX DURING MAJOR ORTHOPAEDIC SURGERY

A-103 SYSTEMIC THROMBOLYSIS AND ENDOVASCULAR THROMBECTOMY IN SEVERE ACUTE ISCHEMIC STROKE AFTER DABIGATRAN REVERSAL WITH IDARUCIZUMAB

Impact of a rare disease on public health today and tomorrow: the case of haemophilia

Summary

Haemophilia is a rare X-linked disease of coagulation, implying a partial or a complete deficiency of circulating factor VIII, in case of haemophilia A, or factor IX, in case of haemophilia B. If untreated, the bleeding tendency in patients with haemophilia may induce spontaneous bleeding episodes leading to serious complications, including premature death. Substitutive treatments consisting of intravenous infusions of clotting factor VIII or IX concentrates, which can be administered in a preventive or curative way, are presently available. To be effective, there is a need to administrate the correct dosing of clotting factors. The optimal substitutive treatment dosing of factor VIII concentrates in haemophilia A is addressed in relation to morphometric variables in the first section of this thesis. However, current treatments for haemophilia have some limitations and the development of new treatments through clinical studies would be beneficial. Factors influencing the motivation of patients to participate in clinical studies to develop new treatments are addressed in the second section of the thesis. Finally, this work was integrated in a general public health perspective by investigating the health and the economic burden of haemophilia in Belgium in the final section. The consumption of coagulation factors needed to treat haemophilia and its associated cost is steadily increasing in Belgium and other developed countries. For the first time the total economic burden of haemophilia in Belgium was estimated. In addition, the disease burden related to haemophilia in Belgium was quantified through Disability-Adjusted Life Year (DALY) calculations.

(BELG J HEMATOL 2016; 7(3):123–6)

P1.15 Multiple Myeloma in Black Africans, clinical and biological characteristics

A-108 Belgian multicenter study into von Willebrand Disease (B-Will Study): First results

The Use of Temporary Central Venous Catheters for Optimizing Continuous Infusion in Hemophilia Patients Undergoing Major Surgical Procedures

Value and implications of the anti-Xa activity monitoring in pregnant women receiving prophylactic LMWH: a retrospective study