BJH - volume 15, issue 8, december 2024
O. Mortelé PhD, K.L. Wu MD, PhD, K. Verboom PhD, P. De schouwer MD, E. Heylen PhD
This case report outlines the diagnosis and management of T-cell prolymphocytic leukaemia (T-PLL) in a 78-year-old asymptomatic woman. The leukaemia rapidly progressed within five months, leading to a hyperleukocytosis of 305 × 109/L and thrombopenia suggestive for bone marrow involvement. Diagnostic assessments included peripheral blood analysis, immunophenotyping, cytogenetics and molecular analysis according to the unified diagnostic criteria of the T-PLL International Study Group (T-PLL-ISG). Bendamustine treatment was initiated resulting in a significant decrease in leucocytosis. In the past nine months, the patient has received six cycles of bendamustine and has remained asymptomatic to date.
(BELG J HEMATOL 2024;15(8):325–8)
Read moreBJH - volume 11, issue Abstract Book BHS, february 2020
M. Metsers , N. Steinfort , E. Heylen PhD, P. De schouwer MD, K.L. Wu MD, PhD
BJH - volume 11, issue Abstract Book BHS, february 2020
N. Steinfort , M. Metsers , D. Breems MD, PhD, K.L. Wu MD, PhD, P. De schouwer MD, E. Heylen PhD
BJH - volume 10, issue 6, october 2019
E. Van Valckenborgh PhD, M. Bakkus PhD, E. Boone PhD, A. Camboni MD, PhD, J-P. Defour PhD, B. Denys MD, H. Devos MD, L. Dewispelaere MD, G. Froyen PhD, A. Hébrant PhD, P. Heimann MD, PhD, P. Hermans MD, PhD, E. Heylen PhD, K. Jacobs PhD, F. Lambert MD, M. Le Mercier Apr, PhD, E. Lierman PhD, H. Louagie MD, PhD, B. Maes MD, PhD, M-B. Maes PhD, G. Martens MD, PhD, L. Michaux MD, PhD, F. Nollet PhD, MSc, H.A. Poirel MD, PhD, G. Raicevic PhD, P. Saussoy MD, PhD, T. Tousseyn MD, PhD, M. Van Den Bulcke PhD, P. Vandenberghe MD, PhD, K. Vandepoele PhD, P. Vannuffel PhD, T. Venken PhD, K. Vermeulen PhD
Molecular diagnostics have an increasing impact on diagnosis, risk stratification and targeted treatment in haemato-oncology. In the framework of a pilot study for the implementation of next-generation sequencing in the Belgian healthcare system, the Commission of Personalised Medicine was founded to give professional and evidence-based advice on the molecular analysis in haemato-oncology. This paper describes its recommendations for NGS analysis in myeloid malignancies. In addition, the minimally required set of genes that must be analysed is defined and algorithms for molecular workflow in myeloid malignancies are proposed.
(BELG J HEMATOL 2019;10(6):241–9)
Read moreBJH - volume 10, issue 2, march 2019
B. Heyrman MD, E. Heylen PhD
A 75-year-old patient presented with fluctuating swelling around the eyes, vasculitis at the lower legs and back of the upper legs and an extreme hypogammaglobulinaemia. An extensive work-up revealed the presence of secondary immunoglobulin M cryoglobulinaemia related to a monoclonal B-cell lymphocytosis. Precipitation of proteins also resulted in a decreased C1-esterase inhibitor causing angioedema. She was treated with an elderly chronic lymphocytic leukaemia regimen consisting of obinutuzumab and chlorambucil with a subsequent clinical and haematological remission.
(BELG J HEMATOL 2019;10(2):85–8)
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