BJH - volume 7, issue Abstract Book BHS, january 2016
F. Nollet PhD, MSc, P. Vannuffel PhD, C. De Rop , S. Vermeire , D. David , B. Cauwelier MD, PhD
BJH - volume 7, issue Abstract Book BHS, january 2016
B. Cauwelier MD, PhD, S. Vermeire , W. Rosseel , F. Nollet PhD, MSc
BJH - volume 7, issue Abstract Book BHS, january 2016
M. Criel , S. Vermeire , B. Cauwelier MD, PhD, F. Nollet PhD, MSc
BJH - volume 7, issue Abstract Book BHS, january 2016
B. Cauwelier MD, PhD, S. Vermeire , E. Maelbrancke , K. Vanhouteghem PharmD, F. Nollet PhD, MSc
BJH - volume 6, issue Abstract Book BHS, january 2015
J. Dauw , E. Boone PhD, N. Cardinaels MD, E. Moureau , A. Nijs , F. Nollet PhD, MSc, V. Van Hende MD, N. Van Roy PhD, K. Van Eygen MD
BJH - volume 5, issue 4, december 2014
B. Depreter PhD, PharmD, E. Dumoulin PharmD, J. Billiet MD, B. Cauwelier MD, PhD, B. Maes MD, PhD, C. Matthys MD, J. Van Droogenbroeck MD, F. Nollet PhD, MSc, J. Emmerechts MD, PhD
We report a rare case of biclonal biphenotypic B-cell lymphocytosis with chronic lymphocytic leukaemia phenotype. Clonality was initially misjudged by immunophenotyping because of its polyphenotypic pattern. Polymerase chain reaction analysis revealed clonality of the immunoglobulin heavy chain and kappa light chain gene rearrangement, indicating the presence of a monoclonal B-lymphocyte population. Immunophenotyping was repeated after cell sorting and revealed two CD5+CD19+ populations with different light chain restriction. Different genetic abnormalities for both clones, as evidenced by fluorescence in situ hybridisation and hypermutation analysis, support the diagnosis of two independently originated but co-existing B-cell clones. This case illustrates the importance of using multiple techniques in the diagnostic work-up of haematological malignancies.
(BELG J HEMATOL 2014;5(4):143–7)
Read moreBJH - volume 5, issue Abstract Book BHS, january 2014
B. Depreter PhD, PharmD, F. Nollet PhD, MSc, S. Vermeire , B. Cauwelier MD, PhD, A. Van Hoof MD, PhD, J. Billiet MD
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