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H. Deckmyn PhD

Articles

The biochemistry of platelet function regulation

BJH - volume 11, issue 6, october 2020

C. Tersteeg PhD, H. Deckmyn PhD

SUMMARY

Blood platelets are playing a key role in maintaining the integrity of the vascular system or haemostasis, however they can become detrimental when activated at sites of e.g. atherosclerosis, potentially leading to thrombosis or occlusion with devastating effects. To prevent this, a number of antiplatelet agents is currently used in the clinic. However, all antiplatelet agents are accompanied with an increased risk of bleeding, and hence the search for better and safer compounds is ongoing. In this effort, a good understanding of the biochemistry of platelet activation is of primordial importance. In the present review, we intend to bring together the current knowledge on platelet behaviour in thrombosis and haemostasis in a coherent manner by subdividing the entire process into different steps: platelet adhesion, activation, amplification, aggregation, shape change and clot retraction, as well as inhibition of platelet activation and aggregation.

(BELG J HEMATOL 2020;11(6):240-5)

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P30 VWF DEFICIENCY IS ASSOCIATED WITH RETICULOCYTOSIS AND INCREASED PARASITE ACCUMULATION IN EXPERIMENTAL MALARIA-ASSOCIATED ACUTE RESPIRATORY DISTRESS SYNDROME

BJH - 2019, issue ?, february 2019

S. Kraisin , S. Verhenne , T.-T. Pham , K. Martinod , I. Portier , N. VanDePutte , H. Deckmyn PhD, K. VanHoorelbeke PhD, P.E. Van Den Steen , S.F. De Meyer PhD

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P28 THE MECHANISM OF THE LOSS OF HMW VWF MULTIMERS AFTER LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION IS DIFFERENT BETWEEN HUMANS AND SHEEP

BJH - 2019, issue ?, february 2019

S. Deconinck , A.-S. Schelpe , S. Jacobs , C. Nix , S. Barth , H.B. Feys PhD, N. VanDePutte , C. Tersteeg PhD, H. Deckmyn PhD, S.F. De Meyer PhD, B. Meyns , K. VanHoorelbeke PhD

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P27 VON WILLEBRAND FACTOR DEFICIENCY DOES NOT INFLUENCE ANGIOTENSIN I I-INDUCED ABDOMINAL AORTIC ANEURYSM FORMATION IN MICE

BJH - 2019, issue ?, february 2019

I. Portier , K. Martinod , L. Desender , N. VanDePutte , H. Deckmyn PhD, K. VanHoorelbeke PhD, S.F. De Meyer PhD

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P22 ANTI-CUB1 OR ANTI-SPACER ANTIBODIES THAT INCREASE ADAMTS13 ACTIVITY ACT BY ALLOSTERICALLY ENHANCING METALLOPROTEASE DOMAIN FUNCTION

BJH - 2019, issue ?, february 2019

A.-S. Schelpe , A. Petri , N. VanDePutte , H. Deckmyn PhD, S.F. De Meyer PhD, J.t.b. Crawley , K. VanHoorelbeke PhD

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P21 A NOVEL ADAMTS13 CONFORMATION ELISA SHOWS CONFORMATIONAL ACTIVATION OF RAT ADAMTS13 WITH EXPOSURE OF CRYPTIC EPITOPES IN VITRO

BJH - 2019, issue ?, february 2019

C. Dekimpe , L.c. VelÁsquez Pereira , J. Voorberg , H. Deckmyn PhD, S.F. De Meyer PhD, K. VanHoorelbeke PhD

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O07 THE VWF-GPIB INTERACTION MEDIATES THROMBO-INFLAMMATION IN EXPERIMENTAL STROKE VIA RECRUITMENT OF MONOCYTES, NEUTROPHILS AND T-CELLS TO THE BRAIN

BJH - 2019, issue ?, february 2019

F. Denorme , K. Martinod , A. Vandenbulcke , C.v. Denis , P.j. Lenting , H. Deckmyn PhD, K. VanHoorelbeke PhD, S.F. De Meyer PhD

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