BJH - volume 15, issue 7, november 2024
J. Neefs PharmD, T. Van Nieuwenhuyse PharmD, A. Janssens MD, PhD
SUMMARY
Bruton’s tyrosine kinase inhibitors (BTKis) have demonstrated impressive clinical activity and tolerability in several B-cell malignancies, both as single agents and in combination with anti-CD20 monoclonal antibodies. The reimbursement for zanubrutinib, a next-generation BTKi, has recently been extended by the Belgian national public health insurance from Waldenström macroglobulinaemia (WM) to chronic lymphocytic leukaemia (CLL) and marginal zone lymphoma (MZL). This review describes the mechanism of action, dosage and administration, efficacy, and tolerability of zanubrutinib.
(BELG J HEMATOL 2024;15(7):269–80)
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BJH - volume 14, issue 2, march 2023
J. Brijs MD, J. Neefs PharmD, A. Janssens MD, PhD
SUMMARY
Lymphomas are the most common haematological malignancy and represent a heterogenous group of lymphoproliferative diseases with a variable prognosis. Chemotherapy and radiotherapy, and anti-CD20 immunotherapy for B-cell lymphomas, currently form the basis of lymphoma treatment. New agents, especially new forms of cancer immunotherapy, such as bispecific antibodies (bsAbs), have expanded therapeutic approaches in the last years. bsAbs have two different antigen binding sites, which enables them to simultaneously target tumour cells and immune effector cells (T-cells). By binding and activating T-cells in the proximity of tumour cells, an effective T-cell mediated anti-tumour response can be achieved. Target antigens in lymphomas are mostly CD19 or CD20 on the malignant B-cell and CD3 on the T-cell. This article will briefly review the basic principles and mechanisms of action of bsAbs, discuss the molecules approved or in advanced clinical development for lymphomas with their most relevant (dose-escalation/dose-expansion) trials, and pay attention to possible adverse events and future perspectives of bsAbs.
(BELG J HEMATOL 2023;14(2):67–72)
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