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J. Philippé MD, PhD

Articles

Juvenile myelomonocytic leukaemia: the quest for more specific therapies

BJH - volume 5, issue 4, december 2014

H. Helsmoortel PhD, T. Lammens PhD, N. Van Roy PhD, J. Philippé MD, PhD, P. De Paepe MD, PhD, Y Benoit MD, PhD, F. Speleman PhD, P. Van Vlierberghe PhD, B. De Moerloose MD, PhD

Summary

Juvenile myelomonocytic leukaemia is a very rare, aggressive stem cell disorder predominantly affecting infants and young children. Current survival rates are disappointing and the only available curative therapy is haematopoietic stem cell transplantation. Over the last years, intensive research efforts elucidated a plethora of molecular aberrations involved in the pathogenesis of juvenile myelomonocytic leukaemia. Current investigations are mainly directed towards the complete unravelling of the molecular biology behind the disease in order to find more specific drugs. This review will focus on the diagnosis, genomic characterisation and the use of experimental therapies in juvenile myelomonocytic leukaemia.

(BELG J HEMATOL 2014; 5(4): 119–24)

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P4.13 CMYB expression during in vitro hematopoiesis from human embryonic stem cells

BJH - volume 5, issue Abstract Book BHS, january 2014

S. Vanhee , K. De Mulder , Y. Van Caeneghem , S. Taveirne , N. Van Roy PhD, B. Menten , S. Bonte PhD, G. Verstichel , G. Goetgeluk , M. Dullaers , J. Philippé MD, PhD, T. Taghon , G. Leclercq , T. Kerre MD, PhD, B. Vandekerckhove MD, PhD

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