BJH - 2018, issue Abstract Book BHS, february 2018
K. Saevels MD, A. Van De Velde MD, PhD, S. Anguille MD, PhD, A. Verlinden MD, A. Gadisseur MD, PhD, W. Schroyens MD, PhD, Z. Berneman MD, PhD
BJH - 2018, issue Abstract Book BHS, february 2018
A. Devos , P. Maes MD, H. Daenens , K. Saevels MD, A. Van De Velde MD, PhD
BJH - volume 8, issue 7, december 2017
K. Saevels MD, Z.N. Berneman MD, PhD, S. Anguille MD, PhD
Paroxysmal nocturnal haemoglobinuria is a rare, acquired haematological disease that manifests with haemolytic anaemia, thrombosis and impaired bone marrow function. The absence of two glycosylphosphatidylinositol-anchored proteins, CD55 and CD59, leads to uncontrolled complement activation that accounts for haemolysis and other paroxysmal nocturnal haemoglobinuria manifestations. Patients may present with a variety of clinical manifestations, such as anaemia, thrombosis, kidney disease, smooth muscle dystonias, abdominal pain, dyspnoea, and extreme fatigue. Delayed recognition of this condition is common due to the variable clinical presentation. This delay in diagnosis confers an increased risk of mortality and morbidity. Therefore, the purpose of this review is to raise awareness about this potentially life-threatening disease among haematologists and to provide a guide to diagnosis and treatment.
(BELG J HEMATOL 2017;8(7):259–64)
Read moreBJH - volume 7, issue Abstract Book BHS, january 2016
K. Saevels MD, K. Clotman , A. Verlinden MD
BJH - volume 6, issue Abstract Book BHS, january 2015
D. Dierickx MD, PhD, K. Saevels MD, G. Verhoef MD, PhD, M. Delforge MD, PhD, T. Devos MD, PhD, A. Janssens MD, PhD, J. Maertens MD, PhD, H. Schoemans MD, PhD
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