BJH - 2021, issue 2, march 2021
M. Beckers MD, PhD, S. Sid MD, A. De Becker MD, B. Heyrman MD, N. Granacher MD, D. Mazure MD, S. Meers MD, PhD, M.C. Vekemans MD, On behalf of the other members of MDS and MPN committee
Chronic myelomonocytic leukaemia (CMML) is a rare haematological disease. Hallmark of the diagnosis is chronic monocytosis. Other clinical features include cytopenia, dysplasia with the associated complaints like fatigue or leucocytosis, splenomegaly with constitutional symptoms. Predicting prognosis and choosing the correct treatment can be challenging for the clinician. These guidelines cover the diagnosis and treatment of CMML and provide information on morphology, cytogenetics and molecular testing, clinical features including autoimmune manifestations, prognosis and risk assessment and a treatment algorithm for both the fit and unfit CMML patient.
(BELG J HEMATOL 2020;12(2):66-76)
Read moreBJH - volume 12, issue 1, february 2021
M.C. Vekemans MD
Myelodysplastic syndromes (MDS) are a very heterogeneous group of clonal disorders of hematopoietic stem cells that are associated with cytopenias and a propensity to evolve to AML. In the recent years, significant progresses have been achieved to better understand the diversity of clinical, cytogenetic, molecular and immunological factors that are bound to the prognosis and outcome of patients with MDS. Their implementation into conventional risk stratification models should further refine patient subgroups, improve predictive value for survival and provide a next-generation classification and prognostic system for these patients, in order to assist personal treatment decision.
(BELG J HEMATOL 2021;12(1):38-46)
Read moreBJH - volume 11, issue 8, december 2020
N. Meuleman MD, PhD, M. Vercruyssen MD, M. Cliquennois MD, J. Caers MD, PhD, C. Doyen MD, G. Bries MD, PhD, C. Jacquy MD, PhD, M. Delforge MD, PhD, M.C. Vekemans MD
Immunoglobulin light chain (AL) amyloidosis is a rare and serious disease due to the deposition of amyloid fibrils. In the past years, improvements have been made in the diagnosis, treatment and response criteria. Based on an extensive review of the recent literature on AL amyloidosis, we propose practical recommenddations that can be used by Belgian haematologists as a reference for daily practice. Management of other types of amyloidosis will not be covered by this review. Levels of evidence and grades of recommendations are based on previously published methods.1 We recommend participation in clinical trials to gain knowledge in this evolving field.
(BELG J HEMATOL 2020;11(8):343-56)
Read moreBJH - volume 11, issue 8, december 2020
M.C. Vekemans MD, C. Doyen MD, K.L. Wu MD, PhD, A. Kentos MD, PhD, P. Mineur MD, L. Michaux MD, PhD, J. Caers MD, PhD, N. Meuleman MD, PhD, M. Delforge MD, PhD, On behalf of the BHS Myeloma Subgroup
With the introduction of immunomodulatory drugs, proteasome inhibitors and anti-CD38 monoclonal anti-bodies, major improvements have been achieved in the treatment and outcome of multiple myeloma (MM). Different treatment combinations are now in use and other therapies are being developed. This rapidly changing therapeutic landscape urges for an update on practical guidelines. Based on an extensive review of the recent literature, we propose recommendations on myeloma management, to be used by haematologists as a reference for daily practice.
(BELG J HEMATOL 2020;11(8):357-75)
Read moreBJH - volume 11, issue 8, december 2020
M.C. Vekemans MD, J. Morelle MD, PhD
Monoclonal gammopathy of renal significance (MGRS) represents a heterogeneous group of diseases in which a monoclonal immunoglobulin, secreted by a plasma or B-cell clone with no evidence of malignancy, causes renal damage. As MGRS patients have a high risk of developing permanent kidney damage, adequate diagnosis and treatment are required to preserve kidney function. In this review, we address the definition, mechanisms and classification of MGRS, and discuss how patients with suspected MGRS should be evaluated and managed.
(BELG J HEMATOL 2020;11(8):376-80)
Read moreBJH - volume 11, issue 7, november 2020
M.C. Vekemans MD, C. Doyen MD, K.L. Wu MD, PhD, A. Kentos MD, PhD, P. Mineur MD, L. Michaux MD, PhD, J. Caers MD, PhD, N. Meuleman MD, PhD, M. Delforge MD, PhD, On behalf of the BHS Myeloma Subgroup
With the introduction of immunomodulatory drugs, proteasome inhibitors and anti-CD38 monoclonal antibodies, major improvements have been achieved in the treatment and outcome of multiple myeloma (MM). Different treatment combinations are now in use and other therapies are being developed. This rapidly changing therapeutic landscape urges for an update on practical guidelines. Based on an extensive review of the recent literature, we propose recommendations on myeloma management, to be used by haematologists as a reference for daily practice.
(BELG J HEMATOL 2020;11(7):286-304)
Read moreBJH - volume 11, issue 5, september 2020
M.C. Vekemans MD
For the first time, in the context of the COVID-19 pandemic, the annual congress of EHA was turned into a full virtual edition, focusing on haematological innovations and evidence-based knowledge of primary clinical evidence. We choose to report ten abstracts of clinical interest that may have a direct impact on our daily practice.
(BELG J HEMATOL 2020;11(5):197-202)
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