BJH - volume 7, issue Abstract Book BHS, january 2016
S. Amat , T. Tamakloe , N. Meité , V. Havelange MD, PhD, M.C. Vekemans MD, C. Lambert MD, PhD, E. Van den Neste MD, PhD, X. Poiré MD, PhD
BJH - volume 6, issue 5, december 2015
K. Beel MD, PhD, M.C. Vekemans MD, G. Bries MD, PhD, J. Caers MD, PhD, B. De Pryck MD, K. Fostier MD, A. Kentos MD, PhD, N. Meuleman MD, PhD, P. Mineur MD, I. Van de Broek MD, PhD, K.L. Wu MD, PhD, C. Doyen MD, M. Delforge MD, PhD
Immunoglobulin light chain amyloidosis is a clonal plasma cell dyscrasia, historically associated with a very poor prognosis. Prompt diagnosis is critical to preserve organ function and improve survival in immunoglobulin light chain amyloidosis patients. The severity of cardiac involvement and response to treatment are the most important prognostic factors. Serum free light chain ratio and cardiac biomarkers troponin T and N-terminal pro-brain natriuretic peptide are powerful tools for the evaluation of prognosis and treatment response. Historically, treatment with autologous stem cell transplantation appears to offer a survival benefit, but is only an option in a minority of patients. IMiDs, and especially proteasome inhibitors, have shown promising activity in immunoglobulin light chain amyloidosis. Supportive care should be integrated in the treatment plan and requires a multidisciplinary approach. These guidelines summarise a consensus of the myeloma subcommittee of the Belgian Hematological Society on diagnosis, cytoreductive and supportive treatment of immunoglobulin light chain amyloidosis, based on an extended review of the literature. Where applicable, comments were added with respect to the Belgian reimbursement modalities.
(BELG J HEMATOL 2015;6(5):187–94)
Read moreBJH - volume 6, issue Abstract Book BHS, january 2015
C. Cornil , E. Collinge MD, G. Di Prinzio , A. Devresse , J-P. Defour PhD, P. Saussoy MD, PhD, L. Michaux MD, PhD, L. Knoops MD, PhD, M.C. Vekemans MD, A. Ferrant
BJH - volume 6, issue Abstract Book BHS, january 2015
E. Collinge MD, A. vanden Daelen , L. Marot , A. Camboni MD, PhD, J-P. Defour PhD, P. Saussoy MD, PhD, L. Michaux MD, PhD, M.C. Vekemans MD, L. Knoops MD, PhD
BJH - volume 6, issue Abstract Book BHS, january 2015
P.D.M. Katoto , N. Vanlangendonck , V. Havelange MD, PhD, X. Poiré MD, PhD, C. Lambert MD, PhD, M.C. Vekemans MD, A. Ferrant , V. Lannoy , E. Van den Neste MD, PhD
BJH - volume 6, issue Abstract Book BHS, january 2015
G. Di Prinzio , C. Cornil , E. Collinge MD, A. Devresse , P.D.M. Katoto , V. Havelange MD, PhD, E. Van den Neste MD, PhD, X. Poiré MD, PhD, M.C. Vekemans MD
BJH - volume 6, issue Abstract Book BHS, january 2015
A. Dermine , J. Dewulf , J-P. Defour PhD, M.C. Vekemans MD
Top
