M. Hofmans MD, PhD

P10 Translocation (12;22) with TEL-MN1 (ETV6-MN1) fusion transcript: a recurrent, but rare genetic abnormality in acute myeloid leukaemia: case report and review of the literature

P30 Severe pancytopenia as presenting feature in newly diagnosed multiple myeloma (NDMM): a rare presentation

A case report of a paediatric Early T-cell Precursor Lymphoblastic Leukaemia

SUMMARY

We describe a case of a four-year-old boy diagnosed with an Early T-cell Precursor Lymphoblastic Leukaemia. This type of leukaemia is recognised as a high-risk subgroup characterised by very early arrest in T-cell differentiation. Early T-cell Precursor Lymphoblastic Leukaemia cases have characteristic gene expression profiles, increased genomic instability and a distinct immature immunophenotype (CD1a–, CD8–, CD5^+dim and positivity for at least one marker of stem cell or myeloid lineage). This type of leukaemia is associated with poor prognosis and a poor response to intensive chemotherapy, though this finding is still debated. Our patient displayed an inferior response to induction therapy. The main purpose of this report is to make Belgian physicians aware of this entity and its controversial prognostic significance.

(BELG J HEMATOL 2017;8(2):75–9)

P21 Bone marrow necrosis with E. coli marrow invasion in a patient with secondary diffuse large B-cell lymphoma : a rare cause of pancytopenia

P4.03 Introduction of Type and Screen testing in patients from the hematology and oncology department: comparison with blood cross-matching