BJH - volume 11, issue 2, march 2020
C. Hossay MD, M-M. Dolmans MD, PhD
In recent decades, major progress has been made in cancer diagnosis and therapy, significantly extending the life expectancy of cancer patients and thereby dramatically increasing demand for fertility preservation. Indeed, of all cancers arising in women worldwide, ~15% occur in those aged <45 years, while ~40% of cancers affecting girls <20 years of age are of haematological origin. Furthermore, patients requiring chemotherapy and/or radiotherapy are at risk of premature ovarian failure. This review discusses different strategies aiming to preserve and protect fertility: embryo and oocyte cryopreservation; ovarian tissue cryopreservation; fertility-sparing surgery; gonadoprotective strategies; and new avenues of research like the artificial ovary and in vitro maturation of primordial follicles.
(BELG J HEMATOL 2020;11(2):44–8)
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