BJH - volume 13, issue 8, december 2022
M. Mulder MD, PhD, L.S. Boerenkamp MD, N. van Yperen MD, G.J. Oudhuis MD, PhD, A.M. Oude Lashof MD, PhD, E.A. Beckers MD, PhD
This case report describes the diagnosis and treatment of hepatosplenic candidasis (or chronic disseminated candidiasis) in a young man with acute myeloid leukaemia (AML). The disease is characterized by persisting fever during treatment with broad-spectrum antibiotics after neutropenia. Sometimes the preceded candidemia is detected. The diagnosis can be made, using radiographic imaging (CT scan/PET scan), supported by histologic examination of a (liver) biopsy. Cultures can be negative. The β-D-glucan test and PCR assays might be of supportive value. Long-term antifungal medication (several months) is necessary. In some cases, fever only disappears after the start of corticosteroids.
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