BJH - volume 10, issue Abstract Book BHS, february 2019
J. Finalet Ferreiro , T. Tousseyn MD, PhD, O. Gheysens MD, PhD, G. Verhoef MD, PhD, M. André MD, PhD, P. Vandenberghe MD, PhD, L. Buedts PhD, L.M. Fornecker , J. Lazarovici , R. Casasnovas , C. Copie , L. Marcelis MD, PhD
BJH - volume 6, issue 4, october 2015
N. Cardinaels MD, D. De Ruysscher MD, PhD, K. Poesen MD, PhD, O. Gheysens MD, PhD, C. Doyen MD, M. Delforge MD, PhD
POEMS syndrome is a rare paraneoplastic syndrome that is defined by the presence of peripheral neuropathy, a monoclonal plasma cell disorder, and other paraneoplastic features, of which the most common include organomegaly, endocrinopathy and skin changes.1 We report a case of POEMS syndrome in a 62-year old female who presented with worsening general condition, weight loss, asthenia and diarrhoea. Clinical examination showed the presence of ascites, peripheral oedema and a thickened skin with the presence of glomeruloid hemangioma. Further investigations showed the presence of three isolated FDG-avid bone laesions on PET-CT, a plasmacytoma with lambda restriction on bone marrow biopsy and elevated VEGF serum levels. The patient was treated with local radiotherapy with a total dose of 39 gray. Two months after radiotherapy, the patient already has a good clinical response with a reduction of ascites, fluid retention and diarrhoea, associated with a significant decline in the VEGF level.
After the case description, a review of the literature is presented.
(BELG J HEMATOL 2015;6(4): 156–61)
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