BJH - volume 15, issue 8, december 2024
O. Mortelé PhD, K.L. Wu MD, PhD, K. Verboom PhD, P. De schouwer MD, E. Heylen PhD
SUMMARY
This case report outlines the diagnosis and management of T-cell prolymphocytic leukaemia (T-PLL) in a 78-year-old asymptomatic woman. The leukaemia rapidly progressed within five months, leading to a hyperleukocytosis of 305 × 109/L and thrombopenia suggestive for bone marrow involvement. Diagnostic assessments included peripheral blood analysis, immunophenotyping, cytogenetics and molecular analysis according to the unified diagnostic criteria of the T-PLL International Study Group (T-PLL-ISG). Bendamustine treatment was initiated resulting in a significant decrease in leucocytosis. In the past nine months, the patient has received six cycles of bendamustine and has remained asymptomatic to date.
(BELG J HEMATOL 2024;15(8):325–8)
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