S. Snauwaert MD, PhD

P13 In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

Highlights in lymphoma

SUMMARY

This non-comprehensive summary of abstracts dedicated to lymphoma that were presented at ASH 2017, will focus on Hodgkin lymphoma (HL), follicular lymphoma (FL), primary central nervous system lymphoma (PCNSL) and diffuse large B-cell lymphoma (DLBCL). Although this selection of abstracts is of course biased by personal interest, it aims to give you a relevant overview for daily clinical practice.

(BELG J HEMATOL 2018;9(1):14–8)

O.4 In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

PP4.5 Functional in vitro evaluation of T cells generated from minor H antigen-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

P2.01 Functional evaluation of T cells generated from WT1-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

In vitro generation of AML-specific T-cells from human haematopoietic progenitor cells. A step towards curing acute myeloid leukaemia?

Summary

This dissertation focuses on T-cell-mediated immunotherapeutic strategies for the treatment of acute myeloid leukaemia. Two major key points determine the success of adoptive T-cell therapy: the nature of the target antigen and the characteristics of the infused T-cells. We reviewed potential acute myeloid leukaemia target antigens and performed an in-depth study of the Receptor for Hyaluronic Acid Mediated Motility as a potential leukaemia associated antigen. Subsequently, an alternative immunotherapeutic strategy was studied: the in vitro generation of antigen-specific T-cells starting from T-cell receptor-transduced human haematopoietic progenitor cells.

(BELG J HEMATOL 2014;5(4):154–7)

P.66 TCR-dependency of T cell maturation in OP9-DL1 cocultures