Articles

P58 Immuno-T, a motion comic educating patients and caregivers on how immunotherapy strategies work

BJH - 2018, issue Abstract Book BHS, february 2018

C. Gharakhani Nia , S. Calis , Y. Bertrand , L. Achten , J. Soetens , B Casteels , D. Flamez , E. Bollaert , T. Kerre MD, PhD

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From Minis to TRUCKs: are CARs ready for the highway?

BJH - volume 8, issue 3, june 2017

T. Kerre MD, PhD

SUMMARY

CAR T-cells have revolutionised the treatment of relapsed and refractory B-cell malignancies. Especially in B-ALL, exciting results have been published. This article reviews CAR T-cell design, the optimal T-cell product used, the lymphodepleting regimen preceding the adoptive therapy, successes and toxicities induced by CAR T-cells in clinical trials (especially B cell malignancies), and the future of CARs and their position in the quickly evolving field of targeted therapies and immunotherapy for haematological malignancies.

(BELG J HEMATOL 2017;8(3):94–101)

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O.5 Sequential administration of 5-azacytidine (AZA) and donor lymphocyte infusion (DLI) for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) in relapse after allogeneic stem cell transplantation (SCT): an interim analysis from the Belgian Hematology Society (BHS)

BJH - volume 8, issue Abstract Book BHS, february 2017

X. Poiré MD, PhD, C. Graux MD, PhD, A. Ory , J. Jamart , F. Frédéric , H. Schoemans MD, PhD, P. Lewalle MD, PhD, A. De Becker MD, D. Deeren MD, Z. Berneman MD, PhD, T. Kerre MD, PhD, P. Zachée MD, PhD, D. Selleslag MD, Y. Beguin MD, PhD

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O.4 In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

BJH - volume 8, issue Abstract Book BHS, february 2017

S. Bonte PhD, S. Snauwaert MD, PhD, G. Goetgeluk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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Occurrence of mild spontaneous graft-versus-host disease after autologous stem cell transplantation for multiple myeloma: a case report and review of the literature

BJH - volume 7, issue 2, april 2016

I. Moors MD, L. Noens MD, PhD, T. Kerre MD, PhD

Summary

We present the case of a 68 year old woman with multiple myeloma, who developed mild persistent upper and lower gastrointestinal symptoms, together with a rash and abnormal liver function tests, in the early phase post-autologous stem cell transplantation. Pathology findings were compatible with graft-versus-host disease. Local treatment with corticosteroids resulted in a durable remission of the autologous graft-versus-host disease. A literature review reveals an incidence of mild gastrointestinal graft-versus-host disease in 13% of patients after autologous stem cell transplantation. Severe fatal autologous graft-versus-host disease has rarely been reported, and solely in multiple myeloma patients. In this article we discuss incidence, pathophysiology, outcome and treatment of these entities.

(BELG J HEMATOL 2016;7(2):83–6)

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Allogeneic stem cell transplantation at ASH 2015

BJH - volume 7, issue 1, february 2016

T. Kerre MD, PhD

(BELG J HEMATOL 2016; 7(1):48–52)

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PP4.5 Functional in vitro evaluation of T cells generated from minor H antigen-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

BJH - volume 7, issue Abstract Book BHS, january 2016

S. Bonte PhD, S. Snauwaert MD, PhD, M. Heemskerk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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