Journal issues > Issue 6, October 2024 > Drug-induced agranulocytosis in mixed connective tissue disease: A case report

Drug-induced agranulocytosis in mixed connective tissue disease: A case report

By: T. Van Weyenbergh MD, V. Maertens MD, M. Lins MD

SUMMARY

Interplay between drug-induced agranulocytosis (DIA) and autoimmune disease is widely suggested in literature. However, cases of DIA in mixed connective tissue disease (MCTD) are yet to be reported. A 49-year-old woman taking terbinafine presented with acute fever, parotitis and pericarditis. Laboratory analysis revealed severe inflammation (CRP 434 mg/L) with agranulocytosis, rapidly recovering after terbinafine discontinuation. Furthermore, arthralgias, Raynaud’s phenomenon, scleroderma and anti-U1-RNP positivity confirmed underlying MCTD. This is the first reported case of DIA in an MCTD patient. The slim chance of this co-occurrence and the atypical presentation raise the tantalising question of whether an interaction exists.

(BELG J HEMATOL 2024;15(6):246-8)

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