Journal issues > Issue 6, October 2022 > Genetic drivers of peripheral T-cell lymphomagenesis

Genetic drivers of peripheral T-cell lymphomagenesis

SUMMARY

Peripheral T-cell lymphomas represent an unmet medical need. The paucity of biological studies impedes the development of new treatment strategies. In this doctoral thesis, I leveraged next-generation sequencing technologies to identify new gene fusions in peripheral T-cell lymphomas. These insights were used to engineer cell systems and mouse models, which closely resemble human peripheral T-cell lymphomas. These models are valuable tools to understand the biology of peripheral T-cell lymphomas and provide a rational for new treatment regimens.

(BELG J HEMATOL 2022;13(6):253–5)

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