Journal issues > Issue 4, December 2014 > In vitro generation of AML-specific T-cells from human haematopoietic progenitor cells. A step towards curing acute myeloid leukaemia?

In vitro generation of AML-specific T-cells from human haematopoietic progenitor cells. A step towards curing acute myeloid leukaemia?

By: S. Snauwaert MD, PhD, B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

Summary

This dissertation focuses on T-cell-mediated immunotherapeutic strategies for the treatment of acute myeloid leukaemia. Two major key points determine the success of adoptive T-cell therapy: the nature of the target antigen and the characteristics of the infused T-cells. We reviewed potential acute myeloid leukaemia target antigens and performed an in-depth study of the Receptor for Hyaluronic Acid Mediated Motility as a potential leukaemia associated antigen. Subsequently, an alternative immunotherapeutic strategy was studied: the in vitro generation of antigen-specific T-cells starting from T-cell receptor-transduced human haematopoietic progenitor cells.

(BELG J HEMATOL 2014;5(4):154–7)

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