Journal issues > Issue 8, December 2020 > Monoclonal gammopathy of renal significance

Monoclonal gammopathy of renal significance

By: M.C. Vekemans MD, J. Morelle MD, PhD

SUMMARY

Monoclonal gammopathy of renal significance (MGRS) represents a heterogeneous group of diseases in which a monoclonal immunoglobulin, secreted by a plasma or B-cell clone with no evidence of malignancy, causes renal damage. As MGRS patients have a high risk of developing permanent kidney damage, adequate diagnosis and treatment are required to preserve kidney function. In this review, we address the definition, mechanisms and classification of MGRS, and discuss how patients with suspected MGRS should be evaluated and managed.

(BELG J HEMATOL 2020;11(8):376-80)

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