On September 24th 2024, a webinar was held on the new Belgian Hematology Society (BHS) guidelines on the management of diffuse large B-cell lymphoma (DLBCL). Jan Brijs (UZ Leuven, Belgium & CHU Lille, France), Gilles Crochet (CHU UCL Namur, Site Godinne, Belgium) and Vibeke Vergote (UZ Leuven, Belgium) shared the latest advances in the treatment of DLBCL, both for newly-diagnosed and for relapsing or refractory (R/R) disease. These data were translated to clinical practice by the presentation of the new treatment algorithm adapted to the Belgian reimbursement criteria and the discussion of patient cases seen in daily practice.