Journal issues > Issue 7, November 2024 > Zanubrutinib, a next-generation Bruton’s tyrosine kinase inhibitor

Zanubrutinib, a next-generation Bruton’s tyrosine kinase inhibitor

By: J. Neefs PharmD, T. Van Nieuwenhuyse PharmD, A. Janssens MD, PhD

SUMMARY

Bruton’s tyrosine kinase inhibitors (BTKis) have demonstrated impressive clinical activity and tolerability in several B-cell malignancies, both as single agents and in combination with anti-CD20 monoclonal antibodies. The reimbursement for zanubrutinib, a next-generation BTKi, has recently been extended by the Belgian national public health insurance from Waldenström macroglobulinaemia (WM) to chronic lymphocytic leukaemia (CLL) and marginal zone lymphoma (MZL). This review describes the mechanism of action, dosage and administration, efficacy, and tolerability of zanubrutinib.

(BELG J HEMATOL 2024;15(7):269–80)

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